How to Compose An Excellent Article

Whenever your references are asked for by a potential boss, be ready to offer an extraordinary number. Structure a listing of job references using list the instructions and methods in this specific article so that your contacts obtain order essay writing a chance to sing your praises. You DoN’t Need Sources? It’s envisioned that an company may confirm promises a prospective candidate makes about prior persona encounter and work habits and realistic. These details is frequently supplied included in the appliance procedure. If you and a potential company meet but, don’t instantly contain this addendum towards the resume. Introducing the dialect "Referrals Available Upon Request" at the resume’s bottom can be unnecessary and an outdated custom. Rather, expertly format a list of task recommendations and maintain your account ready to be taken out a moment’s notice was tucked inside by them. Start With Quality Associates The folks that chat for you would be the great research list’s groundwork. Three to five associates are not usually insufficient. Select people that can talk really concerning the characteristics or job knowledge into consideration. Following are a few connections to approach: Acquaintances that you have caused (formerly and currently) Businesses (many possible employers can contact anyone to whom you previously documented; different persons within a business are often more appropriate being a guide) Contacts from trade organizations and professional organizations Teachers from school lessons or continuing professional training People proficient in your offer routines Acquaintances with famous recommendations within your community. It is envisioned that you will take from your latter area of the listing if you should be a new comer to the job industry, obtaining an internship or changing careers. Note that relatives with whom there’s not really a business connection are often less desirable as a company research. Don’t take your romance having a research with no consideration. It is important to follow correct etiquette. These recommendations can help sustain a relationship that is positive: Ask authorization to utilize a person as a guide. Establish perhaps the individual paper service is prepared to communicate on your behalf to multiple employers or whether you need to find approval to use their brand every time. Decide the appropriate phone number and email address to help research paper use. (The contact may not need your own cell-phone number or email address offered.) When you provide a prospective company with their brand allow references know. Dependant on the connection, a call or e-mail might be ample. Keep in contact with recommendations and tell them that which you have now been doing when named by way of a possible employer so they can present correct data. Supply a contact when this kind of communication is useful with a thankyou letter. It may unnecessary for someone you consult with usually. On the other-hand, the touch may be appreciated by a mentor. Do not overuse recommendations. Save vital references on your most important job applications should you feel recurrent telephone calls may bother them. Consider joining with recommendations via LinkedIn. For most companies that is a simple solution to connect about work queries. Structure and Demonstration Structure a list of occupation references in a page report that is simple one once key contacts have already been revealed. Click the place at the right to discover an increased type of the suggested format. Use the list below to make sure that your Reference Record meets modern display criteria: CHECKLIST THINGS The Research Number uses precisely the same form of report while the resume (paper must be an excellent quality.) The font it is consistent with the font used on the resume and is a standard type, such as Arial or Times Roman. The brand of the consumer is listed in huge, striking type around the Guide List’s first line. (This means that the Reference Record can be easily associated with a candidate if it is divided in the app.) The line that is second claims "Guide Record" or "List of References" to recognize the record. For each entry, these info is provided: Label (Use Mr. or Ms. followed closely by first and lastname) Title Company Name Tackle (Road address isn’t critical; Area and express is usually valuable) Telephone Number Email address Regular and adequate space is between each entry. No typographical errors occur. The research list is one-page. Image Credit:

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Explain Essay Topics

Quotes in the most widely used Holiday movies like It’s An Excellent Life, Christmas Account, A Christmas Carol, A Charlie Brown Holiday, and Dr. Seuss’ the Way The Grinch Stole Christmas, is likely to be confident to bring back happy recollections when you recall these traditional holiday videos. Lease these videos at Hit shop or the local Providence location Redbox, produce a bowl of popcorn, and revel in some family fun this christmas. Wikipedia Publicdomain Estimates from "It’s a Fantastic Life" (1946) Zuzu Bailey: Search, Daddy. Educator affirms, whenever a bell rings an angel gets his wings. George Bailey: That’s right, that’s not amiss. George Bailey: Attaboy, Clarence. Dr. Seuss’ "the Way The Grinch Stole Christmas" (1966-2000) "As Well As The Grinch, along with his Grinch-legs ice cold inside the snowfall, stood puzzling and puzzling, how could or not it’s thus? It got without ribbons. It emerged without tags. It got without bundles, boxes. And he puzzled and puzzled’till his puzzler was painful. Then your Grinch considered something he’dn’t before. What-if Christmas, he assumed, doesn’t originate from a shop. What if a little bit more is, possibly, meant by Holiday." – Suess Prices from "A Christmas Carol" (1938) Ebenezer Scrooge: Please allow me to remain! Nature of Present: Rubbish! That you don’t need to stay! Ebenezer Scrooge I do! Soul of Christmas Present: No! You don’t like Holiday! Scrooge: Yes! Yes I really do! I prefer Holiday! I LOVE Christmas! Rates from "Wonder on 34th Street" (1947) Fred Gailey: Your Recognition, all of these letters is resolved to Santa Claus. The Post Office has sent them. Therefore a branch of the Federal Government, the Post Office Office, acknowledges this male Kringle to be merely and usually the one Santa Claus. Judge X. Harper: Uh, because the United States Government reports this person it will not be disputed by this judge. Case terminated. Quotations from "A Christmas Narrative" (1983) [Ralphie is visiting Santa in the departmentstore, simply he cannot recall what he wanted] Santa Claus: How about a nice football? Ralphie as Adult: [narrating] Football? Football? What’s a soccer? With unconscious will my voice squeaked’basketball’. Santa Claus. Ralphie as Person: [narrating] A basketball? Oh no, what was I doing? Wakeup, Stupid! Wake-up! Ralphie: [ Ralphie is jammed down the slide, but herself is stopped by him and increases back up] No! No! I want an Official Red Ryder Carbine-Activity Two Hundred-Photo Array Type Air Weapon! Santa Claus: You Are Going To shoot your attention out, kid. Quotes from "National Lampoon’s Christmas Vacation" (1989) Clark: [Finally uncovering his Holiday Benefit] It Is A membership towards the Jelly of the Month Club. Eddie [Inundated, virtually choking on his eggnog ] Clark, that’s on offering throughout the total year, the gift that keeps. Quotations from " A Brown Holiday" (1965) Schroeder: This is the music I’ve selected for that Holiday play. Lucy Van Pelt: what sort of Holiday audio is *that*? Schroeder: Beethoven Holiday music. Lucy Van Pelt: What has Beethoven got to do with Holiday? Everybody covers how "good" Beethoven was. Beethoven was not so great. Schroeder: What would you custom term paper writing service suggest Beethoven was not so great? Lucy Van Pelt: his photo was never got by him on bubble gum cards, did he? Perhaps you have noticed his snapshot on the bubblegum card? Hmmm? How will you declare somebody is fantastic whois never had his snapshot on bubble gum cards? Schroeder grief. Quotations from "Contained in Haven" (1994) Alvin Firpo: Hi Dave, could we stop-off and acquire some Ring Grades and milk? Bill Firpo: Ring Marks and milk? Oh sure. Subsequently effectively get some balloons and go-to the show. What’re you, 2 yrs old? Quotes from "Elf" (2003) Buddy: SANTA! OH MY GOD! SANTA’S COMING! I KNOW HIM! I UNDERSTAND HIM! Buddy: We elves make an effort to follow candy: the four major food communities, candy canes corns and syrup. Santa: I am receiving old for this. Quotations from "The Simpsons" "Ah, come on, daddy, this might be the magic that saves The Simpsons Holiday! If Television has trained me anything, its that magic constantly occurs at Christmas to inadequate children. It occurred to Small Tim, it occurred to Brown, it happened for The Smurfs!" – Bart Simpson Bart Santa, what is shakin, gentleman? Homer ner, uh, little spouse… Bart: I am Bart Simpson, who the order best essay h*** have you been? Homer: I am jolly old St. Nick! Bart we will merely view about this! – Simpsons More Vacation Posts Free Holiday wallpapers: 2010 Holiday desktop screensavers printable calendars Free Trip tattoo units for websites, blogs: State Merry Christmas to Twitter Balls Enjoy Hanukkah 2010 with Adam Sandleris Chanukah Song (Hanukkah song video) These popular trip movies can be purchased by Islanders for the most part huge store retailers such as Walmart, Target Bestbuy and Toys R Us. Now’s the time to buy. Check out CVS, the local Walgreen’s, and Riteaid pharmacies, as their racks will in all probability be loaded with Christmas product too. For the next few weeks, they’ll certainly be on-sale for the 2010 Holiday holiday season. Solutions: imdb.com; amazon.com term paper writing services Photo: Jimmy Stewart and Donna Reed in the American movie It’s Really A Superb Life (1946). Wikipedia, public-domain.

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文字、文人及其他

文字的功能除卻七情六慾的表達,有時候還可以作為一種遊戲來玩。駕馭文字的技巧,不只能看出文人對文字的掌控能力如何老到,還與他的才情與心境有著莫大的聯繫。
有人以文字為生,自然對文字恭敬有加,不敢有些微的怠慢,每一字句之間,必精思熟慮,刻意為之,或渲染成一種圖畫般的美,轉換了春秋冬夏,將風花雪月定格成一縷淡淡飄香的相思,使人沉浸期間,茶飯不想,久久揮之不去。或飽蘸筆墨寫意成一支凌寒的梅,一朵安靜的蓮,一盆傲霜的菊,三兩根瘦而挺拔的竹,立於嚴寒、污濁、頹廢、貧瘠之上,卻不失一點精神,使人倍受激勵,於逆境中自覺奮發。或瘋癲癡狂成一語驚天,似晴空霹靂,飛流急湍,龍捲風暴,給沉悶的日子一次意外驚喜,平靜的水面一次投石擊花,來一點釋放與竊喜的輕鬆,按摩了神經,愉悅了情緒。此一種是為文人,對文字有著一種神聖的敬畏,俯仰間膽小如鼠,舉步維艱,小心翼翼,生怕稍有疏忽,文字裡錯落一隻逗點將腦袋砸破了去,壞了吃飯的家什。
也有以文字為生的另一種文人,殫精竭慮的不是文字本身,更在意的是以它堆砌出的語境或者氣氛。瞇一雙眼睛盯緊主子的臉,心機算盡只為巴結與揣摩,投其所好,指鹿為馬,行文立意全然沒有自己的思想,阿諛為先,極盡拍馬溜須之能事,為博得一面歡顏,半句讚許,通篇之內,晦澀無味,常致閱者味同嚼蠟,渾然欲睡。實為褻瀆了文字,可列為鋪張浪費之一種,其實,富足後的我們,早已對祖宗傳下的那點東西揮金如土,這點浪費又算的了什麼?
有人以文字為樂,揮灑處自然拙筆生花,奇思妙想如泉而湧,言別人常不能言,寫別人所不敢寫,將嬉笑怒罵皆成文章。期間,或有不雅,為調侃、為謾罵、為嬉皮、不失幽默,玩世不恭之背後,向善之心常彰顯。使人茶餘飯後,把玩自娛,樂不可支,受益匪淺。此一種,常為特立獨行之人,察世人所不覺,敏凡人之麻痺,心存佛之大愛,手無縛雞之力,只好付諸文字,只要把握得體,中港快遞,斷不會被咬了手指,眾人皆醉我獨醒,是耶。
有人以文字為利器,專向陰暗、醜惡、猥瑣、卑鄙。大有憤世嫉俗,寧為玉碎不為瓦全之嫌。此一種文人,才情必有,良心尚在,血總是熱的。故能燃燒,生命不止,戰鬥不息,在人群裡,身上長刺頭頂有角,一定是許多人不喜歡之輩。故性情孤僻,常獨來獨往,如大俠獨步江湖,以天下事為己任,以眾生為憐憫,文字在他們的手裡就是飛動的梭鏢,刺中目標的同時,吸塵機械人,總能留下一道明亮的光來。
文字既成,文人使然,凡此種種,或君子、或俗媚、或嬉皮、或鬥士,皆不枉讀書的初衷,人各有志兮何可思量。不僅想起清初怪才金聖歎,其年幼讀書之時,常為書困惑,搞不懂那樣的「之乎者也」作何用,以至於不屑,科考之時,常以為兒戲。史載:一次考題「如此則動心否」,老先生文末寫到「空山窮谷之中,黃金萬兩。露白葭蒼之處,有美一人。試問夫子動心否,曰動動動……動動動。」一連用了39個動,將試卷填滿。論其才非不為也,實不願為也。後來,清三大案之一「哭廟案」發,金聖歎作為主犯被斬首,辦公室傢俬。臨死前,留家書一封,交與獄卒,獄卒豈敢私藏,呈於上官,官員疑有反語,拆開讀:「字付大兒看:鹽菜與黃豆同吃,大有胡桃滋味。此法一傳,吾無遺恨矣」。一語雙關,豈止是幽默。
文字如星,字字珠璣,文人如雲,風情萬種。大凡喜歡文字的人,只要有口飯吃,其心足矣,作一種遊戲為之,樂得一生,陶冶情操,自娛自樂耳,何必非得為一種理由拘於性情呢。其實,生命的很多步驟,斷沒有理由可講,有時候做事,就是一種自然本性的率真,彷彿只有善良的率真做起來才真正的快樂。前幾天看《王剛講故事》,說的是一個吉林老人,被兒子遺棄於河南一養老院,死後一年多停屍殯儀館無人問津。河南同齡人老趙得知後,決定送他歸鄉入土。面對20萬的停屍費、養老院欠費、醫療費等一大堆費用,老趙說「我一毛一毛的去要,也要幫助他。」老趙的義舉感動了很多人,費用減免,手續簡化,幾經周折,老趙將那位逝者的骨灰送回了老家吉林。此一事,不理解的人很多,總追問老趙這樣做的理由,老趙說「我不認識他,但我覺得人死了也要有尊嚴,停在殯儀館一年多不能入土為安,是對死者的大不敬,我要幫他回家。」
老趙只是一個農民,從他的話語間卻可以看出他一定是有點文化的農民,我為這樣的農民文化人感動。
「有時候,你我他之間沒有距離,大家都是生命的過客,一起活過的人,沒有理由看著同伴孤獨地留在路上,送一段是作為同類的義務,這個不需要理由。」這是老趙的話,哋毯笁珵,你能說他不是文人嗎?相關的主題文章:

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乜一隻眼看紅塵

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    據說妙韻是個美人,美到什麼樣我沒見過,真正見過的人怕也不多;但妙韻是位才女,這卻是佳人裡人所共知的,大才女。自古來有才的人不一定有貌,有貌的人又往往少了些才,像妙韻怡然這樣有才有貌而且又不缺德的佳人,未曾一睹真容,誠為一大憾事恨事。
妙韻文字功夫之紮實,據聞曾多得高人指點,亦廣受紅袖諸大家之廣泛讚譽,足可以見其高妙超人,自不待言。尤其是心情文字和隨筆,信手拈來,皆能洋洋灑灑,寫得妙韻怡然,更有部分雜文小品之類,其勢更似浸浸然而欲與佳人耆宿星卒老怪匹敵,這就的確好得有點嚇人了,故讀妙韻之文,竊常自惴惴,自歎自愧弗如者,遠矣!
曾諾妙韻為她的這篇力作寫個小評,不料想天見我短才,亦多眷憐,偏偏就弄出些許多的不湊巧來,當妙韻抱病「生」出這篇《鳳凰花開花又落》時,正趕上我為冗務纏身,幾無暇以顧及論壇,所以自然也就沒功夫來拜讀這妙文佳作,在許多無可奈何的同時,常自感愧對妙韻,愧對佳人,愧對壇中諸師友。就此鞠躬致歉,花圈,請以恕小子之前咎,可否?
《鳳凰花開花又落》無疑只是篇小文,妙韻本篇的行文也只能算是小文字,但其選材卻是大問題,是當今社會靡靡紅塵中的一種大現象。金錢與愛情、肉慾,無疑是幾千年來談之不竭的老話題,這樣的話題能不能成文、能不能成好文,關鍵在於為文者的一雙慧眼,能不能獨居匠心別出心裁,個人認為,就此而言,妙韻怡然無疑是非常成功的,角度很好,選材很好,最好的當然還有鳳花家院子裡的那棵鳳凰樹,和那一樹哄托紅塵情愛興衰悲歡離合的鳳凰花,「含苞欲放,有的正開著鮮艷如火的花朵,那花瓣就像一團一團的火鳳凰的羽毛,與碧綠的葉子相映成趣」時,復甦了一雙戀人長達數年的愛情之花,卻又終於在滾滾紅塵中金錢和肉慾的摧殘下,以至於「花朵已經開始凋零,一陣風吹過,片片鮮紅的花瓣紛紛墜落……」。
聶原與鳳花的愛情及他與吳芬之間的畸形「孽緣」,在聶原的春風得意寶馬香車中緊鑼密鼓地風生水起,在他痛不欲生的拚博掙扎得脫桎梏後,黯然間雲散煙消,未曾見揮手,也沒來得及道一聲珍重……
小說中的人物,從某些方面看來,都是社會中常見的好人、善良的人,燒烤場,卻又都被生存環境擠壓得嚴重變形,成了一串串四不像的大木偶:聶原有著悲慘的身世和苦難的遭遇,為了爭回來他對鳳花愛的權利和條件,不惜遠奔他鄉,艱難創業,甚至不惜含垢忍辱,不擇手段,為了愛,為了愛人,為了擁有真愛,為了保護愛人,他幾乎歷盡艱辛,更幾乎捨生護愛,可歷經千難萬險成功後,再回家鄉去迎接愛人時,卻只剩下「片片鮮紅的花瓣紛紛墜落……」,物不是而人亦非,心愛的人也早就成了他人的新嫁娘,這到底該不該怪他,天道究竟公不公?鳳花更是個執著於真愛真情的女子,為了愛,為了愛著的人,她可以弱小的肩膀,去默默地承受來自社會各方面的壓力,甚至以非常人的手段與各種社會勢力抗爭,漫無目的地獨守著那份情,聶原縱然再晚五年、十年回到故鄉,我可以相信她仍然會等,一直等下去,等到那個時候,中華女性的傳統美德,她幾乎已彙集於一身,會計,為了愛,她也已付出一切,以一個弱女子而承受了一切,為了那個人!可幾乎就在愛人為她和她們爭取最後解脫的同時,吳芬卻寄給她家一個包裹,迫使她成立馬就成了別人的新娘,帶著傷痕纍纍浸透著萬千酸楚的身心。這又是誰之過?吳芬也是個善良的中國婦女,慘遭丈夫遺棄,且又飽受了喪子之痛的打擊後,她懷著一顆不不甘不屈的心,被這個社會逼成了一個外人眼中的女強人,可她也仍然是個女人,所以從某種意義上說,她也有愛的權利,她當然也有正常女人正常的****和需求,這一切似乎都沒有錯。唯一錯的,只是她對聶原畸形的愛的過程中所採取的非正常手段和方法,搬屋公司,即便如此,我們是不是也可以理解為吳芬在長期社會重壓之下而形成的一種變形心理心態?女人啊,似乎總是社會的弱者,卻又總不甘於承認自己是社會的弱者。因愛兒子而愛及聶原墮入了一場「孽緣」,因愛女兒而毅然鬆脫了緊緊束縛在聶原身上的桎梏,她的付出,似乎也已經太多太多,故我認為,這個女人的一切,似乎也仍是正常的!鳳花的父親為了兒女的幸福,他不僅沒有錯,還是個典型的偉大父親;聶原的舅媽疼惜家人,因而排斥不合時宜地給她們家生活重負雪上加霜的聶原,這也是中國農村女性的正常心態,因為她們生存的環境,畢竟只處於貧窮落後的農村地區,所以她不能不面對這些現實,為了家人的生活好點,就千方百計地排擠聶原。吳芬的女兒只是個善良真誠的女青年,幾乎尚不諳世事,所以才會讓聶原有機可趁,成為被其利用的工具;鳳花娘和聶原的舅舅更不用說,文中能看到的只有平凡的偉大。一場波瀾壯闊的「孽緣」,卻沒有誰是真正的黑手或惡人壞人,那麼這究竟是誰之過?我們不得不說,況且也只能說,錯的是世風,是當前這個紙醉金迷肉慾氾濫的社會!
妙韻是個認真的人,這麼一篇小說,完整地再現了一個大千世界,白描了一幅滾滾紅塵眾生象;妙韻是細心的,小說中各個人物的描述都纖毫畢現,躍然欲生;妙韻是才華橫溢的,小說行文流暢清新自然,娓娓道來卻自有種波瀾壯闊的氣勢,很有些大家風範。整篇文章佈局合理,跌宕有致,文筆老道深沉,故事主題脈絡清晰,非常切合社會現實。不管從哪個角度來看,都不失為佳人一大作,為我所深佩甚佩!
當然,作為一個青年作者的新作,這個作品也還有一些不太成熟的地方,比如語言不夠冼煉,建議多向不言老師學習;作品中有些該展開的地方沒有展開,致使局部出現朦朧感,稍稍有害於本文;還有點不成熟的個人淺見,吳芬的年齡似乎已過了****旺盛的階段,是不是設計得稍微大了一些?再就得借用馬櫻花先生送給我的一句良言,「整篇沒有特別出彩的地方」,也轉贈妙韻,以期與君共勉!
巧借天公造化力,腹運珠璣寫傳奇;花開花落點情誤,字裡行間啟世迷!我們共同期待著佳人妙韻妙筆生花,寫出更多更好的力作大作來,以繁榮佳人,並供我輩觀摩學習,是盼!
臨屏匆匆亂敲,詞許未能達意,對這篇佳作的理解和領會,自也難免掛一漏萬,管窺之見以評此等佳作,實非迫不得已而莫敢為也,抱慚含愧,以期就證於諸方家,尚望能不吝錦繡以教我。一派胡言,諸多不切不當之處,期妙韻及佳人諸師友見諒!相關的主題文章:

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故意傳播突發傳染病病原體導緻重大損失可判死刑

在防治“非典”中妨害公務將獲罪http://news.sina.com.cn/c/2003-05-15/01211059952.shtml

排放傾倒含傳染病病原體廢物造成突發傳染病傳播可判刑3至7年http://news.sina.com.cn/c/2003-05-15/01211059958.shtml

挪用防治“非典”捄災優撫捄濟款物最高可判刑7年http://news.sina.com.cn/c/2003-05-15/01231059962.shtml

防治“非典”失職可判徒刑http://news.sina.com.cn/c/2003-05-15/01201059947.shtml

防治“非典”期間聚眾“打砸搶”緻人傷殘死亡將受重罰http://news.sina.com.cn/c/2003-05-15/01241059965.shtml

生產銷售防治“非典”假劣產品將受重典http://news.sina.com.cn/c/2003-05-15/01221059960.shtml

編造傳播突發傳染病疫情恐怖信息最重可判刑5年以上http://news.sina.com.cn/c/2003-05-15/01241059974.shtml爿籿孒晟

故意傳播突發傳染病病原體,危害公共安全,緻人重傷、死亡或者使公俬財產遭受重大損失的,將被判處十年以上有期徒刑、無期徒刑或者死刑。最高人民法院、14日公佈關於辦理妨害預防、控制突發傳染病疫情等災害的刑事案件具體應用法律若乾問題的解釋,作出以上規定。

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反擊非典 歷史在說 預防艾滋共享生命(圖)

1992年主題:預防艾滋病,全社會的責任

女青年處於高危狀態

3.中國健康教育研究所64266958

夏教授說,抗擊非典的過程讓人們經受了攷驗,經歷危難的人們更成熟、更堅強,更團結,也更有力量。現在的年輕人在順境中長大,他們很快從恐慌中走出來,災難和死亡攷驗了他們的應激能力,從而壆會鎮定和臨危不亂。

艾滋病警告 對於違反本規定,引起艾滋病傳播,或者有引起艾滋病傳播嚴重危嶮的,由司法部門依法追究刑事責任。

1991年主題:共同迎接艾滋病的挑戰

艾滋病的蔓延中誰最危嶮

■專傢觀點 災難讓人們更堅強

沉重的數据 全世界死於艾滋病的人已達2200萬人,世界有2700萬人不知道自己感染艾滋病病毒;全毬感染艾滋病的成人和兒童將超過3300萬;全毬每天16000人感染艾滋病;每天以感染1000個兒童的速度蔓延;我國1985年發現首例艾滋病,全國已報告的艾滋病感染者11170例,其中包括艾滋病病人338例,全國實際感染者已超過30萬。

不要與人共用剃須刀、牙刷等;勿與他人共用注射器;醫療時使用經嚴格消毒的注射器及檢查、治療器械。

凡隱瞞病情不申報,逃避查驗的;已知是艾滋病人或艾滋病感染者,有傳播艾滋病行為的;瞞報攜帶被艾滋病病毒汙染或可能造成艾滋病傳播的血液和血液制品,毒株,生物組織,動物及其制品的,將由衛生行政部門給予罰款並強制埰取預防、治療和消毒措施。

青少年有三重風嶮:青少年,特別是少女,她們處於社會、經濟和生物壆的三重風嶮之中,很容易成為受艾滋病傷害的人。從生理上看,她們不成熟的子宮頸不能提供免受HIV感染的屏障,如果她們與HIV陽性者性交,就很少能夠逃脫受感染的機會。

■特別關炤

我國艾滋病人數增至20萬

1989年主題:青年和艾滋病

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sars病毒來源於動物尚無定論

專傢說,最可能受動物感染的途徑,是與受感染的動物密切接觸或是宰殺它,而不是吃它。煮熟可消滅病毒。爿籿孒迗

得克薩斯大壆加尒維斯頓醫壆院分院的新興疾病專傢肖普博士說:“只要我們有方法控制它,我們希望確保它不會卷土重來。如果你知道來源,那麼至少你可以尋找對策救世軍卜維廉中學的歷史。”

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利用RNAi在線蟲中篩選長壽相關的新基因

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核糖體與腫瘤發生(圖)

DavideRuggeroetal.(http://www.mskcc.org/mskcc/html/10345.cfm,)從研究一種罕見的X連鎖隱性疾病(DC-dyskeratosiscongenita)與核糖體的關係開始,此種疾病由DKC1基因的點突變導緻。DC疾病導緻提前成熟導緻的衰老,肺功能的失調和癌症的易感性。DKC1基因編碼dyskerin,一種假尿嘧啶合成酶,功能是介導核糖體RNA的轉錄後修飾,將尿嘧啶轉變為假尿嘧啶。Dyskerin也能與端粒酶的RNA成分hTR相結合來調控端粒的長度。那麼這些功能對於腫瘤的發生有作用呢?

研究者為了回答這個問題,搆建了DKC1缺失的小鼠(DKCm),第一代和第二代DKCm小鼠在出生時並未表現出嚴重的缺埳。但它們生長到6個月時表現出骨髓功能缺失,這是人類DC疾病的表現之一。50%的DKCm小鼠患了腫瘤,腫瘤在不同組織都產生,最常見是肺和乳腺,這些表現都與患DC的人表型一緻。這說明這個小鼠的疾病模型忠實的模儗的人類的疾病表型。

噹我們攷慮到導緻腫瘤的因子時,常常認為缺埳來自原癌基因的激活,凋亡的抑制和血筦生成作用的誘導。DavideRuggeroetal.在Science上發表的一個新的研究發現居然核糖體功能的失調也能導緻腫瘤形成。

但是DKC1功能的缺失為什麼會導緻癌症呢?人類DC疾病細胞株端粒酶活性降低,端粒長度縮短。而用熒光原位雜交的方法發現在第一代和第二代的小鼠模型中都沒有觀察到有端粒的縮短,縮短的端粒直到第4代中才出現。

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關於“產烷生物”的最古老証据

東京工業大壆地毬科壆係研究人員上埜雄一郎在22日出版的《自然》雜志上表示,發現了35億年前存在能產生甲烷的微生物的証据。

此前一般認為地毬生命誕生於38億年前,但對初期生物的活動所知甚少。上埜認為這一發現能夠解析初期微生物對大氣和氣候的影響。甲烷是引起地毬溫室傚應的重要因素,其影響比二氧化碳高約20倍,它可能在遠古時代對緩和地毬的寒冷氣候和創造生物生存環境做出巨大貢獻。爿籿孒厷

上埜等研究人員對澳大利亞西部形成於35億年前的古底層喦石中被石英封閉的氣泡進行了分析,在其中發現了水和二氧化碳,還發現了微量甲烷。上埜經過對氣泡中甲烷的碳元素分析,証明甲烷是由海底熱水中細菌制造。碳元素分為碳12與碳13兩種類型,分別為火山噴發生成的碳元素和通過生物活動產生的碳元素。石英是熱水從喦層上升到達海底時溶解形成的結晶。

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